比索洛尔治疗充血性心力衰竭患者的疗效

Therapeutic Effect on Bisoprolol Fumarate for Congestive Heart Failure

目的：经强心、利尿、扩管药物治疗无改善且伴有快速室率的慢性充血性心力衰竭（CHF）加用小剂量的比索洛尔治疗。方法：46例原有抗心力衰竭治疗的基础上加比索洛尔首次剂量1．25mg。每3d加用1．25mg，每24h口服1次，2周达5mg／d，观察2-6周。结果：心率由106．68±14．28减至68．64±8．62／min，心脏射血分数由（35．42±5．22）％上升至（43．28±6．02）％，且心功能改善总有效率达91．3％。结论：凡常规治疗后效果不佳且伴有快速心室率的CHF患者，可合用小剂量的比索洛尔治疗，常取得满意的疗效。

Objective： Congestive heart failure （CHF） patients through treatment of cardiotonics, diuretics, vasodilators no improved and along with rapid ventricle rates combinate small dosage of Bisoprolol Fumarate to therapy. Methods： 46 CHF patients treated by original methods combinate Bisoprolol Fumarate, the first time dosage is 1.25 milligrams, add 1.25 milligrams every 3 days, oral administration one time per 24 hours, two weeks later reach 5 milligrams per day, observe 2 to 6 weeks. Results： Cardiac rates reduce from 106.68 ± 14.28 times per minute to 68.64 ± 8.62 times per minute, cardiac ejection fraction increase from （35.42 ± 5.22） % to （43.28 ± 6.02）%, the total effect of cardiac function reach 91.3 %. Conclusion： After convention treatment, but not improved and the patient who accompany rapid ventricle rates, add small dosage of Bisoprolol Fumarate to therapy, always obtain satisfactory curative effect.