早期大剂量纳洛酮治疗乙醇中毒合并颅脑损伤疗效分析

Analysis of effect of early large dose naloxone on patients with craniocerebral trauma after alcoholism

目的探讨乙醇中毒合并颅脑损伤早期大剂量使用纳洛酮的临床治疗效果。方法82例乙醇中毒合并颅脑损伤病人分成治疗组和对照组,各42例。治疗组早期给予大剂量纳洛酮,其余常规综合治疗2组相同。观察比较2组GCS、觉醒时间、血浆β-EP含量变化及预后情况。结果治疗组在临床治疗有效率、觉醒时间、GCS变化上较对照组有显著差异(P<0.05),且与对照组相比血浆β-EP含量下降极其显著(P<0.01)。结论早期大剂量纳洛酮治疗乙醇中毒合并颅脑损伤可缩短昏迷时间,促进病人神经功能恢复。纳洛酮使用安全,未见毒副作用。

Objective To explore the clinical effects of early large dosage naloxone in the treatment of craniocerebral trauma after alcoholism. Methods Eighty-four patients with craniocerebral trauma after alcoholism were divided into treatment group（42 cases） and control group（42 cases）. The basic treatment in the two groups were the same. Treatment group took high dosage naloxone more. The GCS, waken time,β-EP in plasma,neurological outcome were observed. Results After administration of naloxone, there were significant differences in therapeutic effect, consciousness recovery time and GCS versus control group（P〈0. 05）. Moreover, treatment group got an obvious decrease of β-EP in plasma compared with control group（P〈 0.01）. Conclusion These results indicate that naloxone is beneficial in the treatment of craniocerebral trauma after alcoholism. A successive high dose of naloxone can rapidly decrease the plasma β-EP levels and improve the recovery of coma compared to routine treatment significantly. Furthermore, no side effects and long-time complication were found.