原发性高血压患者血清晚期糖基化终末产物与血清生长因子的相关性研究及对早期肾功能损害的影响

Association of serum advanced glycosylation end products and growth factors and influence on early renal damage in essential hypertension patients

目的探讨原发性高血压患者血清晚期糖基化终末产物(AGEs)与血清生长因子的相关性研究及其对早期肾功能损害的影响。方法用放免法测血小板源生长因子(PDGF)和晨尿微量白蛋白(mALB);用ELISA法测血清AGEs、转化生长因子β(TGF-β)水平;选取mALB120例原发性高血压患者(mALB正常组52例,mALB异常组68例)和正常对照组50例。结果与对照组比较,EH mALB正常组、EH mALB异常组血清AGEs、TGF-β、PDGF显著增高(P<0.01);EH患者AGEs与TGF-β、PDGF呈正相关;mALB与AGEs、TGF-β、PDGF呈正相关;AGEs是早期肾功能损害的独立危险因素。结论AGEs参与了原发性高血压早期肾功能损害的发病机制。

Objective To explore the relationships between plasma advanced glycosylation end products（AGEs） and serum tansforming growth factor-beta（TGF-β）, platelet-derived growth factor（PDGF） respectively,and the influence of growth factors as well as AGEs on early renal damage in patients with essential hypertension（EH）. Methods Serum PDGF and urinary mieroalbumin（mALB） were detected with radioimmunoassay method and serum AGEs, serum TGF-β were detected with en-zyme immunoassay method （ELISA）. Fifty apparently healthy people were serued as control group. The patients were categorized into 52 EH with normal microalbuminuria group and 68 EH with abnormal mALB group. Results AGEs, TGF-β and PDGF were higher in EH with normal and abnormal mALB groups than that in control group（P〈0.01）. In the EH patients, serum TGF-β and PDGF were associated with plasma respectively. Serum TGF-β, AGEs and PDGF were associated with mALB respectively. AGEs was an independent risk factor on EH with renal damage. Conclusion Growth factors and AGEs play a role in the pathogenesis of hypertension and early renal damage.