肥胖者的心脏脂代谢失调
摘要
肥胖与心力衰竭的发生存在着密切的关系。肥胖患者的脂肪移动信号失调,导致非脂肪组织如心肌也出现脂质累积。心脏因脂肪酸过度供应,发生不充分氧化,中间产物如神经酰胺等的累积,导致线粒体功能不全、解偶联、无效循环及活性氧簇的生成,继而使心脏代谢调控失衡,导致收缩功能不全。
出处
《国际心血管病杂志》
2009年第4期219-220,224,共3页
International Journal of Cardiovascular Disease
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