摘要
观察牛磺酸对大鼠马杜霉素中毒时的保护作用。将试验大鼠每天灌服马杜霉素进行染毒,且染毒前1 h腹腔注射牛磺酸保护,染毒5 d,继续注射牛磺酸2 d后处死,测定血清、肝脏、腿肌和心肌的丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性、谷胱甘肽过氧化物酶(GSH-Px)活力和总抗氧化能力(T-AOC)。结果表明牛磺酸组的大鼠血清、肝脏、腿肌和心肌中SOD活性、GSH-Px活力、T-AOC均有所提高,MDA有所降低,与对照组、马杜霉素组比较,差异显著(P<0.01,P<0.05)。牛磺酸可以提高大鼠机体的抗氧化能力,对马杜霉素引起的脂质过氧化具有保护作用。
The protective effect of taurine on toxic rats induced by maduramicin were observed. SD rats were given taurine by intraperitoneal injection, and were given maduramicin by oral after 1 hours. Rats were induced maduramicin for 5 days, but were given tanrine for 7 days. The concentration of MDA, and the activity of SOD, GSH -Px, and T- AOC in serum, liver, skeletal muscle and myocardium were measured respectively. The results showed that the activity of SOD, GSH - Px and T - AOC in taurine groups increased and the concentration of MDA decreased significantly （P 〈 0. 01, P 〈 0. 05 ） compared with the maduramicin group. The antioxidative effect of rats could be increased by taurine and the lipid peroxidation in toxic rats with maduramicin could be reduced.
出处
《中国兽药杂志》
2009年第7期16-19,共4页
Chinese Journal of Veterinary Drug
