血管回声跟踪技术评价冠心病患者颈动脉弹性与肱动脉内皮功能的相关性

Evaluation of correlation between carotid artery elasticity and brachial artery endothelial function in patients with coronary heart disease by ultrasound

目的探讨颈动脉弹性参数与肱动脉内皮功能的相关性。方法冠心病组、冠状动脉粥样硬化组、健康对照组各30例，回声跟踪技术检测颈动脉弹性参数：压力应变弹性系数（Ep）、硬化参数（β）、顺应性（AC）、脉搏波传导速度（PWVβ）和增大指数（AI）；肱动脉袖带加压检测血流介导的内皮依赖性血管舒张功能（FMD）。结果冠心病、冠状动脉粥样硬化患者Ep、β、PWVβ均较对照组增高，AC、FMD减低（P〈0．01）；所有受试者、冠心病组、冠状动脉粥样硬化组、对照组的FMD分别与Ep、β、PWVβ呈负相关，与AC呈正相关，与AI无相关性。结论颈动脉弹性各参数与肱动脉内皮功能呈高度相关，提示回声跟踪技术能早期、定量反映冠心病患者血管的改变，是评价血管内皮功能简便实用的方法。

Objective To explore the correlation between carotid artery elasticity and braehial artery endothelial function. Methods Thirty patients with coronary heart disease （CHD）, 30 patients with coronary atherosclerosis （CA）and 30 control subjects were enrolled in this study. Their carotid elastic parameters including pressure - strain elastic modulus （ Ep ） , stiffness parameter （ β ）, arterial compliance （ AC ）, pulse wave conducting velocity （ PWVβ ） and augment index （ AI ） were measured by echo -tracking technique. Results Compared with control group, Ep, β and PWVβ in CHD group and CA group were increased, AC and FMD were deereased（P 〈 0.01 ）. There was negative correlation between Ep,β,PWVβ and FMD , and there was positive correlation between AC and FMD,while there was no correlation between AI and FMD. Conclusion There is high correlation between brachial artery endothelial function and carotid artery elastic parameters. E - tracking technology can reflect the vascular changes of patients with CAD early and quantitatively, it is a convenient and practical method in evaluating vascular endothelial function.