摘要
目的研究表面磁性膜医用316L不锈钢支架对新西兰大白兔髂动脉新生内膜增殖的影响。方法通过动物体内支架植入，采用定量冠脉造影、光学显微镜图像技术观察不同支架对新生内膜增殖和再狭窄的影响。结果与普通裸支架相比，表面磁性膜支架可以抑制支架植入后的新生内膜增殖和再狭窄，植入3月后应用表面磁性膜支架和普通裸支架的管腔面积分别为（2．78±0．40）mm^2和（2．07±0．62）mm^2，再狭窄率分别为3．3％和16．7％，且可能与磁场强度相关。结论表面磁性膜支架对经皮冠状动脉介入治疗术后的再狭窄可能具有防治作用。
Objective To investigate the effect of superficial magnetic film 316L medical stainless steel stent on neointimal hyperplasia in rabbit iliac artery. Methods Thirty pretreated New Zealand rabbits were enrolled in this study. A magnetic stent was implanted in iliac artery of each rabbit, and a bare-metal stent in the contralateral iliae artery. The effect of intimal hyperplasia and restenosis of two kind stents were assessed by quantitative angiography and histomorphometry after implantation. Results The superficial magnetic film 316L medical stainless steel stent induced a significant reduction in neointimal area [ （2.78±0.40） mm^2 vs （2.07±0.62） mm^2 ] and lower restenosis rate （3.3% vs 16.7%） compared with the bare metal stent after implantation 3 months, maybe related with intensity of magnetic field. Conclusion The superficial magnetic film stent may prevent artery restenosis after percutaneons coronary intervention.
出处
《中华生物医学工程杂志》
CAS
2009年第2期123-126,共4页
Chinese Journal of Biomedical Engineering
基金
基金项目：国家自然科学基金（30470486）
中国博士后科学基金面上资助金（20070410383）
中国博士后科学基金特别资助金（200801439）
关键词
主动脉瓣狭窄
磁力学
血管内膜
不锈钢支架
增殖
Aortic valve stenosis
Magnetics
Tunica Intima
Stainless steel stent
Hyperplasia
