吸入用布地奈德混悬液和硫酸特布他林雾化液雾化吸入治疗慢性阻塞性肺疾病急性加重期疗效分析

Combined therapy of nebulized budesonide suspension plus terbutaline sulphate aerosol inhalation for chronic obstructive disease at acute exacerbation phase

目的：探讨吸入用布地奈德混悬液与硫酸特布他林雾化液雾化吸入治疗慢性阻塞性肺疾病急性加重期（acute exacerbations of chronic obstructive pulmonary disease，AECOPD）的疗效。方法：将65例AECOPD患者随机分为2组，观察组33例，对照组32例，两组均予吸氧、抗感染、静脉氨茶碱及对症等治疗。在常规治疗的基础上观察组给予吸入用布地奈德混悬液和硫酸特布他林雾化液雾化吸入，对照组单用硫酸特布他林雾化液雾化吸入，对两组患者用药7—10天后的临床疗效、血气分析及第一秒用力呼气容积占预计值百分比（FEV，％）变化情况进行对照分析。结果：观察组治疗前后相比PaO2、PaCO2、FEV1％均有显著改善（P〈0．01），两组问各对应指标相比较差异均有统计学意义（P〈0．01）。观察组总有效率为90．9％，对照组为68．86％（P〉0．05），差异无统计学意义。结论：吸入用布地奈德混悬液与硫酸特布他林雾化液雾化吸入对AECOPD能迅速缓解病情，改善肺功能，是治疗AECOPD的有效选择。

Objective： To evaluate the therapy of inhaling nebulized budesonide suspension combined with terbutaline sulphate for treatment of chronic obstructive pulmonary disease （ AECOPD ） at acute exacerbations phase. Methods ： Sixty-five patients with AECOPD were randomly divided into observed group （ 33 cases ） and control group （ 32 cases ）. Both groups were administered the therapy of oxygen inhalation, anti-infection and intravenous aminophylline. On the basis of routine therapy, the patients in the observed group were given nebulized budesonide suspension inhalation and terbutaline sulphate, and the control group were ministered only terbutaline sulphate inhalation;then the clinical manifestation, blood gas analysis, and FEV1% at baseline and 7 - 10 days after treatment were determined. Results：The PaO2 , PaCO2 and FEV1% were significantly different in the treatment group before and after the therapy（ P 〈 0.01 ）. The response rate was 90.9% and 68.8% in the observed group and the control group respectively （P 〉 0.05 ）. The difference was not significant. Conclusions：The therapy of inhaling nebulized budesonide suspension combing with terbutaline sulphate aerosol may effectively relieve the symptoms of AECOPD. It＇s the choice therapy for AECOPD.