山莨菪碱在婴幼儿轮状病毒肠炎中的应用及疗效观察

Observation on Application and Efficacy of Anisodamine on Infantile Rotavirus Enteritis

目的评价山莨菪碱（654-2）在婴幼儿轮状病毒肠炎中的应用及治疗效果。方法1078例住院治疗的轮状病毒肠炎患儿,分为山莨菪碱治疗组及常规治疗组。疗程3-8d。结果（1）第4d山莨菪碱组有效率74.6%,常规组有效率51.3%,差异有统计学意义（χ^2=23.83,P〈0.01）。第4d山莨菪碱组治愈率59.6%,常规组治愈率15.5%,差异有统计学意义（χ^2=153.11,P〈0.01）。治疗结束山莨菪碱组有效率91.9%,常规组有效率74.7%,差异有统计学意义（χ2=57.62,P〈0.01）,治疗结束山莨菪碱组治愈率74.2%,常规组58.1%,差异有统计学意义（χ2=70.84,P〈0.01）。（2）治疗期间两组均无严重不良反应发生。结论山莨菪碱治疗婴幼儿轮状病毒肠炎疗效佳,可缩短病程,减轻症状,促进病情恢复,使用过程中副作用轻,安全性好。

Objective To evaluate the application and efficacy of anisodamine on infantile rotavirus enteritis. Methed A total of 1078 cases were divided into two groups randomly,the treatment group was treated with anisodamine, the routine group was treated with general therapy. The treatment duration of two groups was 3 - 8 days. Results （1）At the fourth day of the therapy, the effective rate in treatment group was 74.6%, while in routine group it was 51.3% （ X^2 = 23.83 ,P 〈 0.01 ）. At the end of the tharapy, the curative rate in two groups was 59.6% and 15.5% （ X^2 = 153.11, P 〈 0.01 ）. The effective rate in two groups was 91.9% and 74. 7%, respectively （ X^2 = 57.62, P 〈 0.01 ）. The curative rate was 74.2% and 58.1%, respectively （ X^2 = 70. 84 ,P 〈0.01 ）. （2） No severe adverse reactions were observed in both groups. Conclutions Anisodamine was safe, reliable and convenient in the treatment of infantile rotavirus enteritis. It may shorten the disease course, reduce the symptoms and promote the restore of the disease with few side reactions.