细丝蛋白A在浸润性乳腺癌中的表达及意义

Expression of filamin A in invasive breast carcinoma and its significance

目的:探讨细丝蛋白A(filamin A,FLNa)在浸润性乳腺癌组织中的表达及其与临床特征之间的关系。方法:采用免疫组织化学和FCM法检测46例浸润性乳腺癌标本中FLNa的表达情况,并统计分析FLNa表达与患者临床病理学特征的相互关系。结果:FLNa在浸润性乳腺癌组织中的表达水平随分化程度的降低而增高,中、高分化组与低分化组之间的差异有统计学意义(P<0.05);有淋巴结转移组的FLNa表达水平较无淋巴结转移组高(P<0.05)。结论:FLNa表达水平与浸润性乳腺癌的侵袭和转移有关,可作为浸润性乳腺癌预后判断的辅助指标,也有望成为临床治疗的新靶点。

Objective ：To study the relationship between the expression of filamin A （FLNa） and clinical pathological features in invasive breast carcinoma. Methods：The expression of FLNa was measured by immunohistochemistry and flow cytometry in 46 cases of invasive breast carcinoma. Results： The expression level of FLNa was increased in poorly differentiated invasive breast carcinoma. There were significant differences between well-moderately differentiated and poorly differentiated groups （P〈0.05）. The expression level of FLNa in invasive breast carcinoma with lymph node metastasis was higher than that in non-metas-tasis group（P〈0.05）. Conclusion ： The level of FLNa expression correlated with invasion and metastasis of invasive breast carcinoma. FLNa can be used as an assistant marker for prediction of breast carcinoma prognosis and has the potential to be a new target for cilinical therapy.