影响干细胞移植治疗心肌梗死效果的因素分析

Factors that affect therapeutic effects of stem cell transplantation on myocardial infarction

急性心肌梗死后如何实现梗死区的再血管化以及延缓左心室重构并恢复心脏的正常收缩功能一直是研究的热点。研究显示,移植的干细胞可在心肌梗死区域定植,同时通过发挥分泌血管内皮细胞生长因子等营养效应和向心肌细胞、血管内皮细胞的分化作用来实现梗死区的再血管化,并能改善心室重构和恢复心脏功能。然而,干细胞对心肌梗死的上述修复作用与干细胞的组织来源相关密切,而且不同的预处理方法也可直接影响到干细胞的修复效果。同时,合适的干细胞供者与受者选择以及移植窗口、移植途径的正确把握是取得良好临床疗效的重要因素。

After acute myocardial infarction, how realizes revascularization of the infarct area as well as prolongs the postponement left ventricle reconstruction and restores heart normal contraction function has been the hot spot. The research demonstrated that the transplanted stem cells may be in field planting of the heart infarct region, simultaneously through nutrition effects of secreting vascular endothelial cells and differentiation into myocardial cells, vascular endothelial cells, and can improve ventricle reconstitution and recovery cardiac function. However, stem cell effects on myocardial infarction have close correlation to stem cell tissue source. Various preconditioning also can affect repair of stem cells. Meanwhile, choice of suitable stem cell donors and recipients, correction of transplanted window and pathway are key factors for obtaining good clinical curative effects.