白塞病患者血清可溶性瘦素受体的检测

Detection of serum soluble leptin receptor in patients with Behcet's disease

目的:检测白塞病(BD)患者可溶性瘦素受体(sLR)水平。方法:应用酶联免疫吸附实验对40例BD患者及30例正常对照组血清sLR水平进行检测。结果:40例BD患者血清sLR水平(72.44±35.33)ng/mL与正常对照组(126.94±33.67)ng/mL相比明显降低(P<0.01);活动期BD患者血清sLR水平(64.24±36.13)ng/mL与稳定期BD患者血清sLR水平(81.50±33.00)ng/mL相比差异无显著性(P>0.05);有关节受累BD患者血清sLR水平(52.72±28.17)ng/mL与无关节受累BD患者血清sLR水平(88.58±32.70)ng/mL相比明显降低(P<0.01)。结论:BD患者血清sLR水平的异常可能影响白塞病的发生与发展。

Objective： To measure the level of soluble leptin receptor （sLR） in the patients with Behcet＇ s disease （BD）. Methods： sLR concentration was measured by enzyme linked immunoabsorbent assay in 40 patiens with BD and 30 matched healthy controls. Results： The mean serum sLR concentration in patients with BD （72.44 ± 35.33） ng/mL was significantly lower than that in healthy controls （ 126.94 ± 33.67） ng/mL, with statistical significance （ P 〈 0. 01 ）. The patients in active stage of the disease （64.24 ± 36.13） ng/mL had lower sLR concentration than that of the patients in inactive stage （81.50 ± 33.00） ng/mL, but the difference was not statistically significant （ P 〉 0. 05）. The patients with arthritis （52.72 ± 28.17 ng/mL） had significantly lower sLR concentration than that in patients with non - arthritis （88.58 ± 32.70） ng/mL, with a significant difference （ P 〈 0. 01 ）. Conclusion： The abnormality of serum sLR level in patients with BD may have an impact on the occurrence and development of the disease.