摘要
目的:分析兰州地区汉族寻常型、关节病型银屑病与HLA-DQB1*0201等位基因的相关性。方法:采用聚合酶链反应-序列特异引物(polymerase chain reaction sequence specific primers,PCR-SSP)法检测41例寻常型银屑病患者、27例关节病型银屑病患者和52名健康对照的等位基因频率。结果:寻常型银屑病患者组HLA-DQB1*0201等位基因频率较正常对照组显著增高;关节病型银屑病患者组HLA-DQB1*0201等位基因频率较正常对照组显著增高。结论:HLA-DQB1*0201等位基因可能是兰州地区汉族寻常型、关节病型银屑病的遗传标志。
Objective： To investigate the association of HLA - DQB1 ＊ 0201 allel with psoriasis vulgaris and psoriasis arthropathica in Lanzhou Han nationality. Methods： High-resolution polymerase chain reaction amplification with sequence specific primers （ PCR - SSP） was used in detection of distribution frequency of HLA - DQB1 ＊ 0201 allele among 41 patients with psoriasis vulgar is, 27 patients with psoriasis arthropathica and 52 healthy controls. Results： The frequency of HLA - DQB1 ＊ 0201 allele was significantly higher in patients with psoriasis vulgaris and psoriasis arthropathica than in controls. Conclusion： HLA - DQB1 ＊ 0201 may be the susceptible allele of psoriasis vulgaris and psoriasis arthropathica in Lanzhou Hans.
出处
《中国麻风皮肤病杂志》
2009年第7期500-502,共3页
China Journal of Leprosy and Skin Diseases
