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银屑病动物模型 被引量:1

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摘要 银屑病是一种慢性炎症性皮肤病,其特点是角质形成细胞的增殖和分化加速,血管生成与血管扩张。它是通过角质形成细胞及T细胞,树突状细胞,炎性细胞因子介导免疫系统相互作用而形成。通过细胞及分子水平研究,目前对疾病的认识已有很大进步,然而导致疾病发生、维持的主要因素仍然不清楚。研究人员曾试图从基因改造、异种器官移植小鼠模型复制银屑病,深入了解其发病机制,并开始使用这些模型,以测试新的治疗药物和界定其作用机制。每一个小鼠模型各有长处和弱点,都有改进的余地,但是,这些模型对银屑病的发病机制的认识和新药的研制是有帮助的。
作者 汪五清 顾军
出处 《中国麻风皮肤病杂志》 2009年第7期523-525,共3页 China Journal of Leprosy and Skin Diseases
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