纳洛酮联合氨茶碱治疗早产儿原发性呼吸暂停疗效观察

Clinical Observation on Effects of Aminophylline Plus Naloxone in Treating Pre mature Infant with Primary Apnea

目的：观察纳洛酮联合氨茶碱治疗早产儿原发性呼吸暂停的疗效。方法：2001—01—2007—12于成都市第六人民医院就诊的原发性呼吸暂停早产儿52例分为治疗组30例和对照组22例。两组均应用氨茶碱治疗呼吸暂停，治疗组加用纳洛酮，首次按0.1静脉推入，继之以0．1以0．03-0．05速度静脉泵入，连用3天。比较两组原发性呼吸暂停的显效率。结果：治疗组显效率和总有效率分别为63．3％（19／30）和93．3％（28／30），对照组分别为31．8％（7／22）和59．1％（13／22）。两组显效率比较差异有显著性意义（XX=5．0424，P〈0．05），总有效率比较差异有非常显著性意义（XX=6．9878，P〈0．01）。结论：纳洛酮联合氨茶碱治疗早产儿原发性呼吸暂停疗效显著。

Objective： To explore the efficiency of aminophylline plus naloxone in treating primary apnea of premature infants. Methods： 51 primary apnea of premature infants in the 64 People＇s Hospital of Chengdu from Jan. 2001 to Dec. 2007 were randomly divided into two groups, observation group （31） and control group （21）, all eases received aminophylline treatment, observation group was added naloxone with an initial dose of 0. 1mg/kg, followed by 0. 1mg/kg with 0.03 - 0. 05mg/ （kg. h） pumped constantly into for 3 days. Results： The significant and total effective rate of the observation group was 63. 3% （19/30） and 93. 3% （28/30）, the significant and the total effective rate of the control group was 31.8% （7/22） and 59. 1%（13/22）. The total effective rate of the observation group was obviously higher than that of control group. Conclusion： Aminophylline plus naloxone in treating primary apnea of premature is effective.