乙型肝炎病毒第1896位点变异与基因分型同肝脏功能的相关性分析

The correlation between hepatitis B virus gene mutation at site 1896 in precore region and genotypes as well as liver function

目的分析乙型肝炎病毒前C区第1 896位点变异与HBV基因型与肝功能指标之间的关系。方法对50例慢性乙肝患者采用测序和荧光定量PCR等方法检测相关指标。结果第1896位点变异患者的ALT水平与野生型患者有显著性的差异;乙型肝炎病毒前C区第1 896位点变异与基因型无关。结论乙型肝炎病毒前C区第1 896位点变异可能与病毒持续侵入肝细胞有关。

Objective To analyze the relationship between hepatitis B virus gene mutation at site 1896 in precore region and genotypes as well as liver function parameters. Methods The fluorescent quantitative PCR and sequencing method were applied to measuring the relevant indicators in 50 pa tients with chronic hepatitis B. Results There was significant difference in ALT level between hepati tis B patients with site 1896 mutation and ones with wild-type; and HBV mutation at site 1896 in pre- core region was unrelated to the genotypes. Conclusion HBV mutation at site 1896 in precore region may be associated with continous viral invasion invasion into hepatocytes.