期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

色素上皮细胞衍生因子与糖尿病微血管病变

Pigment epithelium-derived factor and diabetic microangiopathy
下载PDF
导出
摘要 色素上皮细胞衍生因子(PEDF)是一种多功能糖蛋白,在人体中广泛存在,具有抑制新生血管、营养神经及抗肿瘤等多种功能,并能够同多种细胞因子发生相互作用。近年来研究表明,PEDF与糖尿病微血管病变关系密切。 Pigment epithelium-derived factor （PEDF） is a muhifunctional glycoprotein with anti-angiogenic, neurotrophic, and anti-tumor effects. It is widely distributed in a variety of organs and had interaction with many cytokines. Recent studies showed that PEDF had a close relationship with diabetic microangiopathy.
作者 孔德贤 王战建
机构地区 河北医科大学附属第三医院内分泌科
出处 《国际内科学杂志》 CAS 2009年第7期385-387,404,共4页 International Journal of Internal Medicine
关键词 色素上皮细胞衍生因子 糖尿病微血管并发症 视网膜 肾脏 Pigment epithelium-derived factor Diabetic microangiopathy Retina Kidney
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献10

  • 1Barnstable CJ,Tombran-Tink J.Neuroprotective and antian-giogenic actions of PEDF in the eye:molecular targets andtherapeutic potential[].Progress in Retinal and Eye Research.2004
  • 2Chung C,Doll JA,Stellmach VM,et al.Pigment epitheli-um-derived factor is an angiogenesis and lipid regulator thatactivates peroxisome proliferator-activated receptor alpha[].Advances in Experimental Medicine and Biology.2008
  • 3Yoshida Y,Yamagishi S,Matsui T,et al.Positive correlationof pigment epitheliumderived factor and total antioxidant ca-pacity in aqueous humor of patients with uveitis and prolifera-tive diabetic retinopathy[].British Journal of Ophthalmology.2007
  • 4Katakami N,Kaneto H,Yamasaki Y,et al.Increased serumpigment epitheliumderived factor levels in type 1 diabetic pa-tients with diabetic retinopathy[].Diabetes Research and Clinical Practice.2008
  • 5Murugeswari P,Shukla D,Rajendran A,et al.Proinflam-matory cytokines and angiogenic and anti-angiogenic factorsin vitreous of patients with proliferative diabetic retinopathyand Eales′disease[].Retina.2008
  • 6DeCoster MA,Schabelman E,Tombran-Tink J,et al.Neuroprotection by pigment epithelial-derived factor against glutamate toxicity in developing primary hippocampal neurons[].Journal of Neuroscience Research.1999
  • 7Wang JJ,Zhang SX,Lu K,et al.Decreased Expression of Pigment Epithelium-Derived Factor Is Involved in the Pathogenesis of Dia-betic[].Nephropathy Diabetes.2005
  • 8Yamagishi SI,,Adachi H,Abe A,et al.Elevated serumlevels of pigment epithelium-derived factor(PEDF)in the metabolic syn-drome[].The Journal of Clinical Endocrinology.2006
  • 9Petersen,SV,Valnickova,Z,Enghild,JJ.Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization[].Biochemical Journal.2003
  • 10Ogata N.Plasma concentration of pigment epithelium-derivedfactor in patients with diabetic retinopathy[].The Journal of Clinical Endocrinology.2007
国际内科学杂志
2009年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部