摘要
肿瘤坏死因子(TNF)-α是重要的炎症因子,近来越来越多的证据显示其在糖尿病肾病(DKD)的发生发展中起重要作用。实验与临床研究均已经证实,TNF-α在DKD中通过多种机制产生肾脏损伤,而且其活性调节的潜在益处已作为目前临床治疗的一个策略。
Tumor necrosis factor-alpha（TNF-α） is one of the important inflammatory cytokines. There are more and more evidences showed that TNF-α played a critical role in the development of diabetic kidney disease. This review discussed the role of TNF-α as a pathogenic factor in renal injury, focused on diabetic kidney disease, and described potential treatment strategies based on modulation of TNF-α activity.
出处
《国际内科学杂志》
CAS
2009年第7期392-394,398,共4页
International Journal of Internal Medicine
关键词
糖尿病
糖尿病肾病
肿瘤坏死因子
Diabetes mellitus, type 2
Diabetic kidney disease
Tumor necrosis factor-alpha
