期刊文献+

Toll样受体与慢性肝脏疾病的研究进展 被引量:4

Advances of research on toll-like receptors and chronic liver disease
下载PDF
导出
摘要 研究发现Toll样受体(TLR)在慢性肝脏疾病的发生发展中发挥着重要作用。本文将对Toll样受体家族在病毒性肝病、酒精性及非酒精性肝病、自身免疫性肝病、肝纤维化及肝硬化等肝脏疾病发病机制中的研究概况予以介绍。 Along with the development of researches, it found that toll-like receptors played important roles in the pathogenic mechanism of chronic liver diseases. This article reviewed the advances of research on toll-like receptors and chronic liver diseases including viral liver diseases, alcoholic and non-alcoholic liver diseases, autoimmune liver diseases, hepatic fibrosis and cirrhosis.
出处 《国际内科学杂志》 CAS 2009年第7期413-416,共4页 International Journal of Internal Medicine
关键词 TOLL样受体 先天性免疫 非酒精性脂肪性肝病 Toll-like receptors Innate immunity Non-alcoholic fatty liver disease
  • 相关文献

参考文献4

二级参考文献23

  • 1范建高,方继伟,陆元善,钱燕,蔡晓波.U230A芯片动态观察非酒精性脂肪性肝病大鼠肝脏基因表达[J].中华肝脏病杂志,2005,13(8):597-601. 被引量:21
  • 2卢建溪,谢冬英,徐启桓,朱明芬,陈伟,李莉,李刚.阿德福韦治疗过程中乙型肝炎病毒核酸序列的变化[J].中华肝脏病杂志,2006,14(5):331-336. 被引量:7
  • 3阳凯,王琛.宿主细胞应答病毒感染的细胞信号转导研究新进展[J].生物化学与生物物理进展,2006,33(12):1138-1145. 被引量:8
  • 4Kono H,Wheeler M D,Rusyn I et al.Gender differences in early alcohol-induced liver injury:role of CD14,NF-kB,and TNF-α[J].Am J Physiol Gastrointest Liver Physiol,2000;278(4):G652-G661.
  • 5Savas M C,Koruk M,Pirim I et al.Serum ubiquitin levels in patients with nonalcoholic steatohepatitis[J].Hepatogastroenterology,2003;50(51):738-741.
  • 6Yang S,Lin H,Diehl A M.Fatty liver vulnerability to endotoxin-induced damage despite NF-kappa B induction and inhibited caspase 3 activation[J].Am J Physiol Gastrointest Liver Physiol,2001;281(2):G382-G392.
  • 7Nanji A A.Role of kupffer cells in alcoholic hepatitis[J].Alcohol,2002;27(1):13-15.
  • 8Song Z,Joshi-Barve S,Barve S et al.Advances in alcoholic liver disease[J].Curr Gastroenterol Rep,2004;6(1):71-76.
  • 9Su G L.Lipopolysaccharides in liver injury:molecular mechanisms of kupffer cell activation[J].Am J Physiol Gastrointest Liver Physiol,2002;284(4):G256-G265.
  • 10Bowie A,O Neill L A.The interleukin-1 receptor/Toll-like receptor superfarmily:signal generators for pro-inflammatory interleukins and microbial products[J].J Leukoc Biol,2000;67(2):508-514.

共引文献12

同被引文献35

  • 1Dienz O, Rincon M. The effects of IL-6 on CIM T cell responses [J]. Clin Immunol, 2009, 130(1): 27-33.
  • 2Haura EB, Turkson J, Jove R. Mechanisms of disease:insights into the emerging role of signal transducers and activators of transefiption in cancer [J]. Nat Clin Pract Oncol, 2005, 2(6) : 315-324.
  • 3Hsu CP, Chung YC. Influence of interleukin-6 on the invasiveness of human colorectal carcinoma [ J 1. Anticancer Res, 2006, 26 (6B) : 4607-4614.
  • 4Wang H, Justin D, Qiu LW, et al. Targeting leukin 6 signaling suppresses gliomastem cell survival and tumor growth [ J]. J Canc Stem Cell, 2009, 27(9) : 2393- 2404.
  • 5Bollrath J, Phesse TJ, yon Burstin VA, et al. gp130 mediated Stat3 activation in enterocytes regulates cell survival and cell cycle progression during colitis associated tumorigenesis [ J]. Cancer Cell, 2009, 15(2) : 91-102.
  • 6Ancrile B, Lim KH, Counter CM. Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis [ J]. Genes Dev, 2007, 21 (14) : 1714- 1719.
  • 7Naugler WE, Sakurai T, Kim S, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production [J]. Science, 2007, 317(5834): 121-124.
  • 8Greten FR, Eckmann L, Greten TF, et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer [ J ]. Cell, 2004, 118(3) : 285-296.
  • 9Ogata H, Kobayashi T, Chinen T, et al. Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis [J]. Gastroenterology, 2006, 131 ( 1 ) : 179-193.
  • 10Berasain C, Perugorria MJ, Latasa MU, et al. The epidermal growth factor receptor: a link between inflammation and liver cancer [J]. Exp Biol Med Mayweed, 2009, 234(7) : 713-725.

引证文献4

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部