树突状细胞与慢性阻塞性肺疾病

Dendritic cells in chronic obstructive pulmonary disease

慢性阻塞性肺疾病(COPD)是一种慢性炎症性疾病,其病灶局部存在中性粒细胞、巨噬细胞和T淋巴细胞(尤其是CD8+T细胞)浸润。吸烟是COPD发病的首要诱因,目前已证实T细胞对于吸烟所致COPD的发生发展具有重要作用;树突状细胞(DCs)是已知的功能最强的抗原提呈细胞,可激活初始T细胞,在诱导和调节免疫应答中发挥关键作用。近年来发现DCs也存在于COPD病灶中,且其功能和数量均发生了改变,提示其可能与吸烟所致COPD的发病机制有关。

Chronic obstructive pulmonary disease（COPD） is a chronic inflammatory disease, which has polymorpbonuclear neutrophils, macrophages, T-lymphoeytes, particularly CD8^＋ T cells infiltrating in the local lesions. Smoking is closely related with the development of COPD, and activated T-lymphocytes are indicated to be responsible for the progression of COPD. As the most effective antigen-presenting cells, dendritic cells （DCs） can activate naive T-lymphocytes and play a key role in the induction and modulation of immune responses. Recently, DCs are also found in lesions of COPD, with changes of the number and function, so they may play an important role in the pathogenesis of smoking-induced COPD.