Visfatin mRNA在PCOS患者网膜脂肪组织中的表达

mRNA Expression of Visfatin in OmentalAdipose Tissue in Polycystic Ovary Syndrome

目的:探讨visfatin基因在多囊卵巢综合征(PCOS)网膜脂肪组织中的表达及相关影响因素。方法:采用半定量RT-PCR方法检测PCOS组(30例)和对照组(25例)网膜脂肪组织visfatin mRNA表达,并测量体重指数、腰臀比、空腹血糖、空腹胰岛素、胰岛素抵抗指数和血清性激素水平。结果:①PCOS组网膜脂肪组织visfatin mRNA表达量高于对照组(P=0.000)。②网膜脂肪组织visfatin mRNA的表达量与BMI、WHR、FINS、HOMA-IR呈正相关(P<0.05)。③多元逐步回归分析显示,HOMA-IR(P=0.000)和WHR(P=0.005)是影响网膜脂肪组织visfatin mRNA表达的相关因素。结论:网膜脂肪组织visfatin mRNA表达可能与PCOS胰岛素抵抗的发生和肥胖相关。

Objective： To investigate the mRNA expression of Visfatin in omental adipose tissue and its related factors in polyeystic ovary syndrome （PCOS）. Methods： The mRNA expression ofvisfatin was measured using semiquantitative RT-PCR in omental adipose tissue in PCOS group （n=30） and control group （n=25） and body mass index （BMI）, waist to hip ratio （WHR）, fasting plasma glucose （FPG）, fasting insulin （FINS）, insulin resistance index and the levels of serum sexual hormones were measured. Results： ①The mRNA expression of visfatin in omental adipose tissue was significantly increased in PCOS group compared with control group （P=0.000）. ② The mRNA expression ofvisfatin was positively correlated with BMI, WHR, FINS, HOMA-IR （P〈0.05）. ③Multiple regression analysis demonstrated that HOMA-IR （P=0.000） and WHR （P=0.005） were related factors in influencing the mRNA expression ofvisfatin. Conelusions： The mRNA expression of visfatin in omental adipose tissue may be correlated with insulin resistance and obesity.