新鲜羊膜与生物羊膜移植治疗翼状胬肉的疗效对比

Contrative study of treatment of pterygium by fresh amniotic membrane transplantation versus biological amniotic membrane transplantation

目的探讨新鲜羊膜和成品生物羊膜移植治疗翼状胬肉的治疗效果。方法收集初发的翼状胬肉患者60例(78眼),随机分成新鲜羊膜组和生物羊膜组2组,术后观察角膜上皮愈合情况,羊膜移植片成活和动态变化,翼状胬肉的复发率等指标,随访6～12个月。结果手术均一次成功,无免疫排斥反应。3～4d角膜上皮修复,2周左右可见羊膜开始融解、吸收。随访期内新鲜羊膜组有3眼胬肉复发,复发率为7.89%,生物羊膜组4眼发病,复发率为10%,两组间的复发率比较没有统计学差别(P>0.05)。结论新鲜羊膜和成品生物羊膜移植均可降低翼状胬肉术后的复发率,而成品羊膜因取用方便,安全性高而值得推广使用。

Objective To evaluate the efficacy of fresh amniotic membrane transplantation as compared with biological amniotic membrane transplantation in pterygium treatment. Methods Seventy - eight eyes of 60 patients with pterygium were divided into fresh amniotic membrane group and biological amniotic membrane group. They were treated by amniotic membrane transplantation after pterygium excisions. The recurrent rates were observed during the 6 - to - 12 - month follow - up. Results Three（7.89% ） of 38 eyes showed recurrence after fresh amniotic membrane transplantation, and 4 （ 10% ） of 27 eyes showed recurrence after biological amniotic membrane transplantation. There was no significant difference between the two groups （P 〉 0.05 ）. Conclusions The efficacy of fresh amniotic membrane transplantation for preventing primary pterygium recurrence is equivalent to that of biological amniotic membrane transplantation. The biological anniotic membrane can be used easily and safely.