进展期贲门癌术后早期持续腹腔内温热免疫化疗对局部复发的影响

Effect of early CHPPI on peritoneal recurrence for surgery of advanced cardia cancer

目的探讨术后早期持续腹腔内温热免疫化疗治疗进展期贲门癌的临床疗效。方法2005年1月至2006年12月行胸腹联合根治性手术切除的T3、T4进展期贲门癌109例,随机分成腹腔内温热免疫化疗组和对照组,随访观察腹腔内温热免疫化疗对腹膜复发的预防作用。结果腹腔内温热免疫化疗组中腹腔复发率明显低于对照组。结论腹腔内温热免疫化疗是一种安全可行的治疗方法,可降低T3、T4贲门癌患者的腹腔复发率。

Objective To investigate the clinical effect of early postoperative continuous hyperthermic peritoneal perfusion immunochemotherapy （CHPPI） for advanced cardia cancer. Methods A total of 109 patients with serosal invasion who had undergone radical operation were recurited in this study from January 2005 to December 2006. They were randomized into study group （CHPPI） and control group. Multivariate analysis of the SPSS software was used to identify the influencing factors. The peritoneal recurrence rate and complication were followed up. Results The peritoneal recurrence rate were lower in CHPPI group than those in control group. Conclusions CHPPI for gastric cardiac eaneer could degrade peritoneal recurrence, is currently the most effective treatment for peritoneal careinomatosis. More prospective muhicenter randomized clinical trials are needed to optimize the technique and efficacy.