先天性唇腭裂危险因素分析

Analysis on risk factors with congenital cleft lip and cleft palate

目的探讨先天性唇腭裂的危险因素,为预防先天性唇腭裂患儿出生提供科学的依据。方法对先天性唇腭裂患儿285例行1:1病例对照研究。结果家族史情况、孕早期放射线照射情况、毒物接触情况、孕早期感染情况以及孕妇的精神、职业6个因素与唇腭裂的发生有统计学联系(P(0.05)。结论预防先天性唇腭裂患儿的出生,必须作好产前诊断,避免接触环境中的致畸因素,保持孕期身体健康和精神愉快。

Objective To find the methods how to prevent the birth of infants through analyzing the risk factor of congenital cleft lip and cleft palate. Methods A case control study was conducted among the parents of 285 infants with cleft lip and cleft palate and the parents of 285 normal infants who were matched as the control. Results According to simple factor analysis ,6 factors were significantly associated with cleft lip and cleft palate （P 〈 0.05 ）, including family history of cleft lip and cleft palate, ray irradiation, the toxic exposure, early infection, mental stress and job occupation in duration of pregnancy. Conclusions Prevention of congenital cleft lip and palate at birth, prenatal diagnosis must be ready to avoid exposure to teratogenic factors in the environment, and maintain good health during pregnancy and mental pleasure.