抗阿尔茨海默病的胆碱酯酶抑制剂研究进展

Advances in the Researches on Cholinesterase Inhibitors for the Treatment of Alzheimer′s Disease

目前抗阿尔茨海默病的新策略之一是设计具有多靶向的药物。综述抗阿尔茨海默病的胆碱酯酶抑制剂研究的新进展,分类介绍乙酰胆碱酯酶和丁酰胆碱酯酶双重抑制剂、可抑制β-淀粉样蛋白聚集的胆碱酯酶抑制剂、具有抗氧化作用的胆碱酯酶抑制剂、可拮抗H3受体的胆碱酯酶抑制剂以及NO供体型胆碱酯酶抑制剂等多靶向药物,并讨论了各类药物的设计和优化。

One of the current strategies to combat Alzheimer＇s disease （AD） is to design multi-targe- ting drugs. The advances in the researches on eholinesterase inhibitors with multi functions to treat AD were reviewed in this article. These drugs including dual inhibitors of acetyleholinesterase/butyroeholines- terase, dual binding site acetylcholinesterase inhibitors targeting 13-amyloid aggregation, eholinesterase inhibitors with antioxidant functions, dual inhibitor of eholinesterase and H3 receptor and NO-donating cholinesterase inhibitors were introduced, and the design and optimization strategies were also discussed.