海南砂仁挥发油抗炎镇痛止泻的实验研究

Anti-inflammation,analgesic and anti-diarrhea effect of volatile oil from A.longiligulare.T.L.Wu

目的:研究海南砂仁挥发油的抗炎、镇痛及止泻作用。方法:观察不同剂量的海南砂仁挥发油对二甲苯致小鼠耳肿胀和卡拉胶所致大鼠足肿胀的影响,对小鼠热板法痛阈值和冰醋酸所致小鼠扭体次数的影响以及对番泻叶和蓖麻油所致小鼠腹泻的影响。结果:海南砂仁挥发油对二甲苯致小鼠耳肿胀和卡拉胶所致大鼠足肿胀均有抑制作用,其中高剂量组作用与吲哚美辛相当。海南砂仁挥发油对热致痛小鼠可延长其痛阈时间,高剂量组较为明显;对醋酸致痛小鼠,各剂量组可减少其扭体次数,其作用无显著性差异。海南砂仁挥发油对番泻叶所致腹泻有效,对蓖麻油所致腹泻无效。结论:海南砂仁挥发油有一定的抗炎、镇痛和止泻作用,可能是其治疗溃疡性结肠炎的机理之一。

AIM： To study anti-inflammation, analgesic and anti-diarrhea effect of volatile oil from A. longiligulare T. L. Wu. METHODS： The auris-swell model induced by dimethylbenzene and foot edema and swelling model induced by carrgeen were made to study the anti-inflammation effect by different dosage of volatile oil from A. longiligulare T. L. Wu. Tests of hot plate and body wrest were used to study the analgesic effect. The anti-diarrhea function on mice with diarrhea induced by castor oil and folium sennae was observed. RESULTS： Volatile oil from A. longiligulare T. L. Wu could obviously inhibit the auris-swell in mice and the foot edema and swelling in rats, the effect of high dose can equal to that of indometacin. In hot plate test, each dose of volatile oil increased the threshold value of pain significantly, especially the high dose group. The number of mouse＇ s writhe caused by glacial acetic acid was reduced by volatile oil from A. longiligulare T. L. Wu. There was no significant difference between different dose group of volatile oil （P 〉 0.05 ）. It could also decrease the times of wet manure induced by folia sennae, while it was of no effect on diarrhea induced by castor oil. CONCLUSION ： Volatile oil from A. longiligulare T. L. Wu has anti-inflammation, analgesic and anti-diarrhea effect related to the cure for ulcerative colitis.