糖尿病和高血压患者食物IgG抗体产生与脂类代谢

Food IgG antibody and lipid metabolism in patients with diabetes mellitus and hypertension

目的拟探索糖尿病和高血压患者血清中食物IgG水平和脂类的改变。方法美国BIOMERICA食物不耐受检测试剂盒;罗氏Modular PE检测血清脂类。结果螃蟹、虾、鸡蛋为阳性率最高的前3种食物抗体;鸡蛋IgG与高血压有关;高血压和糖尿病组都出现不同程度的脂类代谢紊乱,并且有鸡蛋、牛奶、小麦、螃蟹IgG抗体升高。结论由于中老年人随年龄的增长,肠道屏障作用退化,引起血中IgG抗体升高,进一步加重多种代谢紊乱,值得关注食物IgG检测对降低高血压、糖尿病的发病风险。

Objective To investigate the food IgG level and serum lipids in patients with diabetes mellitus（DM） and hypertension （HT）. Methods BIOMERICA ELISA kit was used to detect food IgG antibodies. Serum lipids were detected with Roche Modular PE analyzer. Results Crab, shrimp and egg were the three foods containing the highest IgG antibodies. IgG antibody in eggs was related with HT. Lipid metabolic disorder occurred in patients with DM and HT. The level of IgG antibodies was increased in egg, milk, wheat and crab. Conclusion The level of IgG antibodies increases in middle and elderly persons due to dysfunction of intestinal and digestive system, and further exaggerates multiple metabolic disorders. Detecting IgG in food helps to decrease the risk of developing HT and DM.