转移性与原发性肝癌血清肿瘤标志物比较

Serum tumor markers of metastatic hepatic carcinoma and primary liver cancer

目的探讨血清肿瘤标志物(TM)在转移性与原发性肝癌中的鉴别诊断和疗效监测价值。方法采用电化学发光法检测174例转移性肝癌和101例原发性肝癌患者血清TM水平。结果转移性与原发性肝癌组比较,AFP、CEA阳性率有统计学差异(P<0.01)。不同组织来源的转移性肝癌中,结直肠和胰腺的CEA阳性率高于其他组(P<0.01),胰腺、乳腺、卵巢的CA125阳性率和胰腺的CA199阳性率均高于其他组(P<0.01)。联合检测阳性率高于单项。结论AFP和CEA是鉴别诊断转移性与原发性肝癌较好的血清TM,不同组织来源的转移性肝癌血清TM变化特点不同,联合检测可提高疗效监测。

Objective To study the role of serum tumor markers （TM） in differential diagnosis of metastatic hepatic carcinoma and primary liver cancer Methods Serum TM levels were measured by electrochemiluminescence technique in 174 cases of metastatic hepatic carcinoma and 101 cases of primary liver cancer. Results There was a statistical difference in positive rate of AFP and CEA between metastatic hepatic carcinoma and primary liver cancer（ P 〈 0.01 ）. The positive rate of CEA in the colon, rectum, pancreas was higher than that of other markers（P 〈 0. 01 ）, while the positive rate of CA125 and CA199 in pancreas, mammary glands, ovary were higher than that of the other markers（ P 〈 0.01 ）. The positive rate of combined detection was higher than that of single detection. Conclusion AFP and CEA are better serum TM for differential diagnosis of metastatic hepatic carcinoma and primary liver cancer. Changes in characteristics of serum TM are different in metastatic hepatic carcinoma of different origins. Combined detection can better monitor the curative effect on metastatic hepatic carcinoma and primary liver cancer.