糖化血红蛋白与糖尿病并发症的相关性研究

Correlation between glycosylated hemoglobin and complications of diabetes mellitus

目的探讨糖化血红蛋白与糖尿病合并并发症的相关性。方法测定糖尿病组(100例)、正常对照组(90例)的糖化血红蛋白及血糖浓度,并对所得资料进行相关性统计分析。结果糖尿病组的糖化血红蛋白(HbA1c)、平均血糖浓度显著高于正常对照组(P<0.01),糖尿病合并并发症组的糖化血红蛋白、平均血糖浓度显著高于糖尿病未合并并发症组(P<0.01),糖尿病组糖化血红蛋白与平均血糖浓度呈正相关(P<0.01),糖化血红蛋白与糖尿病并发症呈正相关。结论糖化血红蛋白与糖尿病并发症的发生率正相关,测定糖化血红蛋白有助于监控糖尿病慢性并发症的发生。

Objective To study the correlation between glycosylated hemoglobin （HbAlc） and complications of diabetes mellitus. Methods Concentration of HbAlc and blood sugar was measured in 100 diabetes mellitus patients （diabetes mellitus group） and 90 healthy volunteers （control group）. The correlation between HbAlc and complications of diabetes mellitus was analyzed by SPSS. Results The concentrations of HbA1 c and average blood sugar were significant higher in diabetes mellitus group than in control group （ P 〈0.01 ）. The average levels of HbAlc and blood sugar were significant higher in diabetes mellitus patients with complications than in those without complications（P 〈0. 01 ）, suggesting that HbAlc was positively related with the average concentration of blood sugar in diabetes mellitus patients （P 〈 0.01 ）. Conclusion HbA1c is positively related with the complications of diabetes mellitus. Assay of HbAlc helps to monitor the occurrence of chronic complications of diabetes mellitus.