肝硬化患者血清瘦素水平的变化及其意义

Significance of the serum leptin levels in patients with liver cirrhosis

目的测定肝硬化患者血清瘦素水平,并探讨其在肝硬化发病过程中的意义。方法采用放射免疫法测定56例肝硬化患者和30例对照者血清瘦素和肝纤维化血清学指标:透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)和层粘蛋白(LN)的水平,同时做肝脏病理活检。结果肝硬化患者的血清瘦素水平和HA、Ⅳ-C、LN均显著高于对照组(P<0.01),且瘦素水平与Child-Pugh分级有关(P<0.01),和HA、Ⅳ-C、LN呈正相关(P<0.01)。结论肝硬化患者的血清瘦素水平明显升高,其可能与肝纤维化的发展相关。

Objective To explore the serum lepfn levels and significance in patients With liver eirrhozis. Methods 56 patients with liver cirrhosis and 30 controlled healthy persons were enlisted in the study. Serum leptin and serological markers of liver fibrosis as hyaluronic acid（ HA）, type Ⅳ collagen（Ⅳ-C） ,laminin （LN） levels were determined by radioimmunoassay. Results The mean serum levels of leptin and serological markers of liver fibrosis as hyaluronic acid （ HA ） , type Ⅳ collagen （ Ⅳ-C ） , laminin （LN） in liver cirrhosis group was significantly than that in thecontrol group （P 〈 0. 01 ）. Serum leptin level in liver cirrhosis group rise gradually accompany with Child-Pugh grade （P 〈0.01 ）. Serum leptin levels in liver eirrhosis group were relevant to the serological markers of liver fibrosis as hyaluronie acid （ HA ）, type Ⅳ collagen （ Ⅳ-C ）, laminin （LN） （ P 〈 0.01 ）. Conclusion Serum leptin levels in patients with liver cirhosis are significantly higher than that in control group and eloely correlated with liver fibrosis.