螺旋藻蛋白激酶对老龄大鼠血液流变学影响的研究

Effect of Spirulina Protein Kinase on Hemorrheology in Aged Rats

目的研究螺旋藻蛋白激酶（SPK）对老龄大鼠血液流变学的影响。方法24-36月龄老年大鼠30只,按随机数字表法随机分为SPK高浓度组（A组）、SPK低浓度组（B组）和老龄对照组（C组）,每组10只,3-4月龄大鼠为成年对照组（D组）,10只。A、B组分别给予SPK混悬液1 g/kg、0.5 g/kg灌服C、D组灌服等量生理盐水,均连续7 d。运用全自动血液流变快速测定仪检测血液流变学各项指标。结果SPK可以降低老龄大鼠的高、中、低切变率下的全血黏度（P〈0.05）,降低红细胞压积和血沉（P〈0.05）。结论SPK可以显著降低老龄大鼠的血液黏度,改善血液流变学特性。

Objective To observe the effect of spirulina protein kinase （SPK） on hemorrheology in aged rats. Methods 30 rats of aged from 24 to 36 months were assigned to the following groups by mean of random number table： high-dosage of SPK （ group A）, low-dosage of SPK （group B） and aged control （group C） ,with 10 in each group. 10 rats of aged from 3 to 4 months was adult controls （group D）. Group A and group B were fed with SPK every day for 7 successive days,group C and group D were fed with normal saline every day for 7 successive days. Some indexes of hemorheolagy were determined. Results SPK decreased the whole blood viscosity in high, middle and low shear rate （ P 〈 0.05）, decreased the hematecrite and erythrocyte sedimentation rate （P 〈 0.05）. Conclusion SPK could significantly decrease the whole blood viscosity of aged rats,improve the characteristics hemorrheology.