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Quantitative Determination of Adrenaline Hydrochloride Injection and Noradrenaline Bitartrate Injection by a New HPLC Method via Substitute for Reference Substance

Quantitative Determination of Adrenaline Hydrochloride Injection and Noradrenaline Bitartrate Injection by a New HPLC Method via Substitute for Reference Substance
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摘要 An HPLC method for quantitative determination of adrenaline hydrochloride injection and noradrenaline bitartrate injection was established and validated with a substitute for the reference substance.Phenylephrine hydrochloride was selected as the substitute for the reference substance of adrenaline and noradrenaline bitartrate.The correction factor of phenylephrine hydrochloride with respect to the reference substance of adrenaline and noradrenaline bitartrate was determined under defined conditions.Adrenaline hydrochloride injection and noradrenaline bitartrate injection were quantified by assaying phenylephrine hydrochloride and a correct factor.The results indicate that the HPLC method with the substitute for reference substance was reliable and feasible for quantitative determination of drugs. An HPLC method for quantitative determination of adrenaline hydrochloride injection and noradrenaline bitartrate injection was established and validated with a substitute for the reference substance.Phenylephrine hydrochloride was selected as the substitute for the reference substance of adrenaline and noradrenaline bitartrate.The correction factor of phenylephrine hydrochloride with respect to the reference substance of adrenaline and noradrenaline bitartrate was determined under defined conditions.Adrenaline hydrochloride injection and noradrenaline bitartrate injection were quantified by assaying phenylephrine hydrochloride and a correct factor.The results indicate that the HPLC method with the substitute for reference substance was reliable and feasible for quantitative determination of drugs.
作者 XIE Yuan-chao HUANG Hai-wei ZHANG Qi-ming JIN Shao-hong
机构地区 Department of Pharmaceutical Analysis Shandong Provincial Institute for Drug Control National Institute for Control of Pharmaceutical and Biological Products
出处 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2009年第4期433-438,共6页 高等学校化学研究（英文版）
关键词 Substitute for reference substance Correction factor ADRENALINE Noradrenaline bitartrate Phenylephrine hydrochloride HPLC Substitute for reference substance Correction factor Adrenaline Noradrenaline bitartrate Phenylephrine hydrochloride HPLC
分类号 TQ460.6 [化学工程—制药化工] Q577 [生物学—生物化学]
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参考文献4

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Chemical Research in Chinese Universities
2009年 第4期

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