摘要
目的通过观察血液动力学及应激反应指标的变化,评价丙泊酚、依托咪酯用于无抽搐电休克治疗的效应。方法100例行无抽搐电休克治疗的精神病患者随机分为两组,分别为丙泊酚组(甲组)和依托咪酯组(乙组)。全麻诱导后,给予琥珀胆碱肌松后行电休克治疗,记录麻醉前、麻醉后、电治疗时、电治疗结束时、呼吸恢复时的MAP、HR。于麻醉前及电治疗结束时抽取肘静脉血2ml。用放免法检测皮质醇(Cor)浓度,以酶免法检测去甲肾上腺素(NE)浓度。结果电治疗后两组病人HR、MAP均明显增高。甲组变化较乙组大(P<0.05)。乙组治疗后Cor浓度、NE浓度均低于甲组(P<0.05)。结论丙泊酚、依托咪酯用于无抽搐电休克治疗效果不同。在保持心血管系统稳定及减少应激反应方面,依托咪酯优于丙泊酚。
Objective To evaluate the effects of Etom Idate and Propofol during MECT. Metheds 100 schizophrenics treated by AECT were randomly divided into two groups： Propofol group（A） and Etom Idate group（B）. Anesthesia was induced with propofol 2mg/kg in group A,Anesthesia was induced with Etom Idate 0. 3mg/kg in groupB. MAP and HR were monitored during MECT. Blood samples were taken before induction of anesthesia and after MECT. Resultes HR andBP after MECT were significantly higher in group A than in group B; The plasma concentrations of cortisol and NE were significantly lower in group B than in group A. Conclution Etom Idate can be used for electroconvulsive therapy with reduced stress yeation and cardiovascular response.
出处
《中国健康心理学杂志》
2009年第6期648-650,共3页
China Journal of Health Psychology
