Survivin及VEGF在大肠癌中的表达及临床意义

EXPRESSION AND CLINICAL SIGNIFICANCE OF SURVIVIN AND VEGF IN COLORECTAL CARCINOMA

目的探讨大肠癌组织中Survivin和VEGF表达、相互关系及临床意义。方法采用免疫组织化学S-P法检测82例大肠癌组织和14例正常粘膜中Survivin和VEGF表达的状况。结果大肠癌组织中Survivin和VEGF表达率分别为67.1%(55/82)和69.5%(57/82),均明显高于正常粘膜组(P<0.05),Survivin表达与大肠癌的Duke s分期有关(P<0.05)。VEGF表达与大肠癌淋巴结转移和Duke s分期有关(P<0.05),与患者的年龄、性别、肿瘤浸润深度及组织分化等其他临床病理因素无关(P>0.05)。在大肠癌中Survivin表达与VEGF和表达呈正相关(rs=0.358,P<0.05)。结论Survivin和VEGF表达在大肠癌发生、发展过程中起重要作用,检测Survivin和VEGF表达水平有助于反映大肠癌进展和预后判断。

Objective To investigate the expression and clinical significance of survivin and VEGF in colorectal carcinoma. Methods Immunohistochemical S-P method was used to detect the expression of Survivin and VEGF in 82 cases of colorectal carcinoma and 14 cases of normal colorectal tissue. Results The expression rate of survivin and VEGF were 67.1% （55/82） and 69.5% （57/82） in colorectal carcinoma, and higher than that in normal colorectal tissue （P〈0.05）, respectively; Survivin protein significantly related with Duke＇s Stage （P〈0.05）, The expression of VEGF had obviously association with lymph node metastasis and Duke＇s stage in colorectal carcinoma （P〈0.05）, and no relationship was observed between the expression of VEGF and age of patients, sex, the depth of infiltration of lesions, histological grading and other clinicopathological manifestations （P〉0. 05） . The expression of Survivin was associated with that of VEGF in colorectal carcinoma （rs= 0. 358, P〈 0.05） . Conclusion Abnormal expression of Survivin and VEGF play an important role in carcinogenesis and progress of colorectal carcinoma. The detect of survivin and VEGF may be useful for evaluating the progress and prognosis of colorectal carcinoma.