Development of Novel Therapeutics to Raise HDL and Block Inflammation

Plant derived phospholipids are rich in linoleic acid (LA) and have therapeutic value to treat inflammatory diseases of the liver,intestine and vasculature. These phospholipids act to normalize plasma lipid levels and prevent atherosclerotic disease. Oral administration of LA-phospholipids to cholesterol-fed rabbits prevents the development of atherosclerosis.

Plant derived phospholipids are rich in linoleic acid （LA） and have therapeutic value to treat inflammatory diseases of the liver, intestine and vasculature. These phospholipids act to normalize plasma lipid levels and prevent atherosclerotic disease. Oral admin- istration of LA-phospholipids to cholesterol-fed rabbits prevents the development of atherosclerosis. Human trials have shown that plant derived phospholipids are safe and can significantly increase plasma HDL-cholesterol levels by up to 20%. Studies in hepatocytes have shown that LA-phospholipids, such as dilinoleoyl phosphatidyleholine （ DLPC）, promote a 4-fold stimulation in HDL secretion,