连续与间歇作用微波消融离体肌组织的对比研究

Comparative study of continuous and interval microwave ablation in ex vivo muscular tissues

目的比较单导植人式微波不同辐射方式消融离体猪肌组织的效果，为临床微波消融治疗子宫肌瘤提供实验数据。方法采用2450MHz微波，相同输出功率，相同作用时间，分别采用连续波和每发射100s间歇10s和20s的间歇辐射方式，进行离体肌组织消融，观察消融区形态、范围、热场温度及病理结果。结果在相同输出功率，相同发射时间条件下，三种作用方式的消融形态、范围、前向距离、热场内温度差异无统计学意义，病理表现相同。结论单导植入式微波连续波辐射与间歇式辐射消融离体猪肌组织的凝固效果无明显差异，可供临床应用参考。

Objective To compare the effect of single implanted microwave ablation in continuous and interval irradiating in ex vivo pig muscular tissues, and to provide the experimental data for microwave ablation therapy of uterine fibroid clinically. Methods The pig muscular tissues ablations were performed with 2450 MHz microwave at same output power and action time. The irradiating modes were set as continuous wave and interval wave （emitting per 100 seconds intermitting 10 seconds and 20 seconds）. The shape,size,thermal field temperature and the pathologic appearance of the ablation zone were evaluated. Results With the same output power and the same action time, the difference observed in the ablated shape, scope, ahead distance and thermal field temperature had no statistical significance, and the pathologic appearances of the ablated zone were same among the different action modes. Conclusions The difference between continuous and interval microwave ablation effects had no statistical significance in ex vivo pig muscular tissues with single implanted microwave. Both of these two modes may apply for uterine fibroid microwave ablation,and may result in same therapeutic efficacy.