控制血压对中老年男性高血压患者下尿路症状的影响

Influence of Blood Pressure Lowering Treatment on IPSS,Qmax in Old and Middle-Aged Male Patients with Essential Hypertension

目的:探讨控制血压对中老年男性高血压患者国际前列腺增生症状评分(IPSS)和最大尿流率(Qmax)的影响。方法:收集安徽安庆农村地区50～75岁男性原发性高血压患者193例,连续4周服用长效二氢吡啶类L型钙离子通道阻滞剂氨氯地平,观察基线血压水平及血压下降水平对IPSS和Qmax的影响。结果:4周后研究人群收缩压和舒张压分别下降了(16.8±16.7)、(8.1±7.7)mmHg(P<0.01);IPSS下降了(2.5±5.5)分(P<0.01),Qmax增加了(0.2±4.7)ml/s(P=0.46)。Qmax变化水平与基线血压及血压变化水平没有显著性差异。IPSS下降水平与血压下降水平没有显著性差异,但与基线血压水平有显著性差异。结论:在中老年男性高血压人群中,控制血压有利于预防和减轻BPH的主观症状。基线血压水平越高,BPH的主观症状经过降压治疗后改善越明显。

Objective： To explore the influence of blood pressure lowering treatment on the International Prostate Syndrome Score （IPSS） and maximum flow rate （Qmax） in old and middle-aged male patients with essential hypertension. Methods： We enrolled 193 hypertensive male patients aged 50 -75 years from the rural area of Anqing, Anhui, treated them with Amlodipine for 4 weeks, and then analyzed the correlation of their baseline blood pressure and reduced blood pressure with the changes of IPSS and Qmax. Results： After 4 weeks of medication, the systolic blood pressure （SBP） and diastolic blood pressure （DBP） of the subjects dropped by 16.8 ± 16.7 and 8.1 ±7.7 mmHg respectively （P 〈 0.01）, IPSS decreased by 2.5 ±5.5 points （P 〈 0.01） and Qmax increased by 0.2 ± 4.7 ml/s （ P = 0.46 ）. Changes of Qmax were not significantly correlated with either the baseline or decreased blood pressure, while changes of IPSS had a significant linear correlation with the former but not with the latter. Conclusion ： Lowering blood pressure in old and middle-aged male patients with essential hypertension can prevent or alleviate the subjective symptoms of benign prostatic hyperplasia, and it reduces IPSS more significantly in those with higher baseline blood pressure.