体细胞重编程——干细胞研究的新希望

Somatic reprogramming： new breakthrough in researches on stem cells

实验性干细胞移植治疗视网膜神经损伤已取得了较好的研究结果，但向临床转化仍存在诸多不可逾越的障碍，特别是种子细胞来源有限、免疫排斥反应、成瘤性及伦理学问题等。体细胞重编程的突破性研究为解决这些问题提供了新的解决方案，进一步解决重编程过程的安全性问题，实现非病毒介导的重编程，将使得干细胞移植向临床转化成为可能。

Replacement therapy of stem cells transplantation represents a potential treatment for neural retinal diseases. Despite the encouraging results in laboratory, the clinical application of cells replacement therapy is still difficult because the limitation of seed cells, immunologic rejection, oneogenicity and ethical problems, etc. Recent breakthrough in somatic reprogramming provides a promising solution overcoming these obstacles. Further researches on virus-free reprogramming will make the clinical application of stem cell replacement therapy possible.