传统型和视神经脊髓型多发性硬化临床特征的比较

Comparison of clinical characteristics between patients with opticospinal and conventional multiple sclerosis

目的:分析和比较视神经脊髓型多发性硬化(OS-MS)与传统型多发性硬化(C-MS)患者的临床特征。方法:在苏州地区收集99例按照McDonald诊断标准(2001)确诊为MS患者(其中C-MS73例,OS-MS26例)的临床资料,并结合实验室及相关检查的结果进行分析比较。结果:与C-MS相比,OS-MS患者中女性更多见,首发症状以视力减退和运动障碍最常见,整个病程中运动障碍、感觉障碍及视力减退的发生率较高,预后较差。2组患者在首次发病年龄、病程等方面未见显著差异。结论:C-MS与OS-MS患者在临床特征方面存在一定的差异。

Objective To compare the clinical characteristics between patients with opticospinal multiple sclerosis （OS-MS） and those with conventional muhiple sclerosis （C-MS）. Methods Clinical materials of 99 patients with MS diagnosed according to the McDonald criteria in Suzhou area were collected （C-MS： 73 cases; OS-MS： 26 cases） and analyzed in coordination with results of laboratory examinations. Results Compared to patients with C-MS, female was more preponderant and prognosis was poorer in patients with OS-MS, initial symptoms were more frequently with visual deterioration and motor weakness, and the prevalence of motor weakness, sensory symptoms and visual deterioration during the course of disease was higher. No significant difference was found in age at onset and course of disease between the two groups. Conclusions There are some differences of certain clinical characteristics between patients with C-MS and OS-MS.