摘要
目的:研究葛根对老年性聋大鼠的治疗作用。方法:选取月龄22～24个月Wistar大鼠32只,随机分为4组,每组8只。对4组大鼠皮下注射不同剂量的葛根提取液,共4周,观察各组大鼠ABR的改变,比较各组动物血液流变学指标。结果:注射葛根后老年性聋大鼠反应阈明显改善(P<0.05),血液流变学指标较对照组明显好转(P<0.05),且葛根注射剂量为2g/(kg.d)效果最佳(P<0.01),不良反应较轻。结论:葛根能明显改善老年性聋大鼠听力。本研究为阐明老年性聋的发病机制及临床上治疗老年性聋提供了理论依据。
Objective：To investigate the preventive effects of Pueraria on presbycusis in rats. Method： Thirty two 24-26 month old Wistar rats were randomly divided into four groups, and were treated with different dosages of Pueraria （1,2,4,0 g·kg^-1·d^-1） seperately for 4 weeks. Auditory brainstem response （ABR） was used to detect the change of hearing threshold of rats. Hemorheological items of rats were checked in each group. Result： Compared with control group, the hearing threshold and hemorheological items of rats was significantly improved after treated with Pueraria（P〈0. 05）. In addition,2 g/（kg · d） was found to be the best dosage of Pueraria for rats, which can achieve ideal effect with minimum side effect. Conelusion：Pueraria could improve tiny circulation, has good preventive effect on presbycusis of rats.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2009年第15期703-705,共3页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
湖北省中医药中西医结合科研课题基金(No:鄂卫发[2007]56)资助
