低分子肝素钙治疗慢性阻塞性肺疾病急性加重期的临床观察

Clinical observation on treating acute exacerbation of chronic obstructive pulmonary disease with nadroparin calcium

目的探讨低分子肝素钙在慢性阻塞性肺疾病急性加重期(AECOPD)中的应用。方法83例慢性阻塞性肺疾病急性加重期的患者随机分为治疗组与对照组。两组患者均予常规治疗,治疗组患者加用低分子肝素钙5000U,皮下注射,每12 h 1次,连续10 d。观察治疗前,及治疗后第1、5、10 d血气分析。结果与对照组相比,治疗组机械通气治疗例数明显减少,住院时间减少,第5、10天动脉血气指标较对照组患者明显改善。结论慢性阻塞性肺疾病急性发作期加用低分子肝素钙可明显提高临床疗效,可以推广使用。

Objective To investigate the application of Nadroparin Calcium in treating acute exacerba- tion of chronic obstructive pulmonary desease （AECOPD）. Methods 83 patients with AECOPD were divided into study group and control group randomly and all received routine treatment. In the study group, patients were extra given subcutaneous injection of Nadroparin Calcium（5000 U）per 12 hours for 10 days. Blood gas analysis was detected before treatment and the 1 st, 5th, 10th day after treatment. Results Compared with the control group, the study group had the advantages of less cases treated by mechanical ventilation, shorter hospitalization time and improved artery gas index at the 5th, 10th day. Conclusions Nadroparin Calcium can improve the clinical effect of treating AECOPD and is worth to population application.