摘要
Chiral monodentate phosphoramidite ligands were conveniently prepared from 1,1'-bi-2-naphthol (BINOL) and (S)-pyrrolidine in good yields, which were effective chiral ligands in the enantioselective rhodium-catalyzed hydrogenation of dehydroamino esters and enamides at low hydrogenation pressure. High conversion rate (up to 99% for dehydroamino esters and enamides) and good enantioselectivity (up to 96.3% ee for dehy- droamino esters and 91.7% ee for enamides) were obtained.
Chiral monodentate phosphoramidite ligands were conveniently prepared from 1,1'-bi-2-naphthol (BINOL) and (S)-pyrrolidine in good yields, which were effective chiral ligands in the enantioselective rhodium-catalyzed hydrogenation of dehydroamino esters and enamides at low hydrogenation pressure. High conversion rate (up to 99% for dehydroamino esters and enamides) and good enantioselectivity (up to 96.3% ee for dehy- droamino esters and 91.7% ee for enamides) were obtained.
基金
Supported by the National Natural Science Foundation of China (20572101)