摘要
目的:探讨WWOX、P53在卵巢上皮性肿瘤中的表达及临床意义。方法:应用免疫组织化学染色方法(SP法)检测95例卵巢上皮性肿瘤,10例正常卵巢组织中WWOX、P53的表达情况。结果:WWOX和P53在卵巢癌组织中呈高表达,与卵巢癌的临床分期、病理分级、组织类型和淋巴结转移有关,二者呈正相关。结论:WWOX和P53联合检测可作为卵巢癌预后的参考指标。
Objective:To investigate the expression of WWOX,P53 protein in epithelial ovarian tumor and its clinicopathologic significance. Methods:The expression of WWOX、P53 in 95 cases of epithelial ovarian tumor,and 10 cases of normal ovarian tissues were studied by immunohistochemistry methods and their clinicopathologic significance were analyzed. Results:WWOX.P53 protein were overexpressed in ovarian carcinoma,the expression was associated with clinical stages.lymphnode metastasis and pathologic grades(P〈0.05) There was a positive correlation between the expression of P53 and WWOX (P〈0.05). Conclusions:WWOX and P53 protein may be a significant prognostic parameter in ovarian carcinoma.
出处
《中国误诊学杂志》
CAS
2009年第23期5548-5550,共3页
Chinese Journal of Misdiagnostics