WWOX、P53在卵巢上皮性肿瘤中的表达及意义

Clinicopathalogic Significance of Expression of WWOX、P53 Protein in Epithelial Ovarian Tumor

目的:探讨WWOX、P53在卵巢上皮性肿瘤中的表达及临床意义。方法:应用免疫组织化学染色方法(SP法)检测95例卵巢上皮性肿瘤,10例正常卵巢组织中WWOX、P53的表达情况。结果:WWOX和P53在卵巢癌组织中呈高表达,与卵巢癌的临床分期、病理分级、组织类型和淋巴结转移有关,二者呈正相关。结论:WWOX和P53联合检测可作为卵巢癌预后的参考指标。

Objective：To investigate the expression of WWOX,P53 protein in epithelial ovarian tumor and its clinicopathologic significance. Methods：The expression of WWOX、P53 in 95 cases of epithelial ovarian tumor,and 10 cases of normal ovarian tissues were studied by immunohistochemistry methods and their clinicopathologic significance were analyzed. Results：WWOX.P53 protein were overexpressed in ovarian carcinoma,the expression was associated with clinical stages.lymphnode metastasis and pathologic grades（P〈0.05） There was a positive correlation between the expression of P53 and WWOX （P〈0.05）. Conclusions：WWOX and P53 protein may be a significant prognostic parameter in ovarian carcinoma.