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新疆维吾尔族5-羟色胺转运体启动子区多态性与焦虑症的关联研究 被引量:1

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摘要 目的探讨新疆维吾尔族5-羟色胺转运体启动子区(5-HTTLPR)多态性与焦虑症的相关性。方法运用聚合酶链反应技术检测38例焦虑症患者和108例健康对照者5-HTTLPR的分布频率。结果共检测出4种基因型:S/S(484bp,484bp),S/L(484bp,528bp)、L/L(528bp,528bp)和S/xL(484bp,616bp),比较发现,患者组和对照组5-HTTLPR的S/S基因型频率分别为16%和39%,差异有显著性(χ2=14.274,P=0.003);S等位基因频率分别为56%和61%,差异无显著性(χ2=0.711,P=0.701)。结论患者组S/S基因型频率低于正常对照组,相关分析结果不支持5-HTTLPR多态性与新疆维吾尔族焦虑症有关。
出处 《卫生研究》 CAS CSCD 北大核心 2009年第4期491-492,共2页 Journal of Hygiene Research
基金 中国科学院心理研究所与新疆大学生命与技术学院合作项目(No.140696) 新疆地方病分子生物学重点实验室开放项目基金(No.XJDX0208-2006-11)
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