慢性胃炎脾胃湿热证胃窦黏膜巨噬细胞移动抑制因子的表达及临床意义

Expression of macrophage migration inhibition factor in antral mucosa of patients with chronic gastritis with Splenogastric hygropyrexia and the clinical significance

目的探讨慢性胃炎脾胃湿热证胃窦黏膜巨噬细胞移动抑制因子(MIF)的表达及临床意义。方法选择慢性胃炎脾胃湿热证30例,脾胃气虚证31例,10名健康体检者作为正常对照组。所有受试者于电子胃镜检查时活检取胃窦组织4块,胃窦黏膜用免疫组化SP法检测MIF的表达。结果正常对照组、脾虚气滞证组中MIF的阳性率分别为10%、54.8%,而脾胃湿热组中阳性率为76.7%,3组比较差异有统计学意义(P<0.05),脾胃湿热证组高于正常对照组和脾虚气滞组。结论慢性胃炎脾胃湿热证炎症程度更甚,部分揭示了慢性胃炎脾胃湿热证的本质,并认为应重视对慢性脾胃湿热证的及时治疗与病情监测。

Objective To investigate the expression of MIF in antral mucosa of patients with chronic gastritis with Spleen - stomach Damp - heat syndrome and the clinical significance. Methods Thirty cases of spleen - stom- ach damp heat （SSDH） syndrome, 31 cases spleen - stomach - qi - stagnation （SSQS） syndrome, and 10 common people were selected as the control group. The expression of MIF was dyed by sp Immunohistochemistry. Results The positive rate expression of MIF were lower in the control group （10%） and the SSQS group（54.8% ） ,hut was high in the SSDH group（76.7% ）. The SSDH group was markedly higher than that of the SSQS group and the control group. The difference of positive rate expression of MIF was obviously significant （ P 〈 O. 05 ）. Conclusion Higher expression of MIF in the SSDH group may be related to higher infection. It may reveal the part essence of SSDH syndrome and suggestion that we should emphasize on timeliness therapy and supervising of the illness.