早期干预对降低早产儿脑性瘫痪的临床研究

Early Intervention can reduce cerebral palsy for pretorm infants

目的探讨早期干预对降低早产儿脑性瘫痪的临床效果。方法2004年10月～2006年12月在我院出生和住院的134例早产儿随机分为两组各67例。除常规保健和治疗外，干预组施行相应干预措施。随访两年后，采用脑瘫发生率和新生儿的智力及运动发育情况进行效果的评估。结果有3例失访，随访率97．8％。干预组脑瘫的发生率较对照组低（x^2=3．85，P=0．049），OR0．151，95％CI0．018—0．956。干预组早产儿的智力和运动发育与对照组在3个月时相当。但在6个月时已有所差异，12～24个月时干预组早产儿的MDI（t=6．13，P=0．000）和PDI（t=4．73，P=0．000）明显均高于对照组。结论早期干预能有效降低早产儿脑瘫发生率，并且对智力及运动发育有明显的提升作用。

Objective We aim to investigate the role for early intervention in reducing cerebral palsy for preterm infants. Methods 134 cases of premature infants were divided into the intervention group and the control group randomly,67 eases each. All the cases were given conventional treatment, and the reducing cerebral palsy interventions were given in the intervention group additional. After two years follow-up,the incidence of cerebral palsy was used to assess the effect, as well as the neonatal development and the exercise of intelligence. Results 3 cases lost,follow-up rate of two years was 97.8%. The incidence of cerebral palsy in intervention group was higher than it in the control group （x^2 = 3.85, P = 0. 049 ） , OR 0. 151,95% CI 0. 018 - 0. 956. At the 3^th months, the intellectual and exercise development of premature infants in two groups was the same; but the 6^th months, it showed the difference ; at the 24^th month, the M DI （ t = 6. 13, P = 0. 000 ） and PDI （ t = 4.73, P = 0. 000 ） in the intervention group was higher than it in the control group. Conclusion The early intervention can reduce the incidence of cerebral palsy in premature infants,and the early intervention can promote mental and motor development at the same time.