鼻咽癌非常规分割放射治疗

Non-conventional Fractionated Radiotherapy for Nasopharyngeal Carcinoma

随着现代放射生物学的进展,肿瘤放射治疗学家对肿瘤细胞增殖特性及单次分割剂量对正常晚期组织放射损伤的影响逐渐有了深刻的理解,并通过改变分割方式来提高肿瘤治疗疗效及减小晚期正常组织损伤。全文就非常规分割放疗中常用的单纯超分割、缩短疗程的加速分割和加速超分割及其与化疗的综合治疗在鼻咽癌治疗中的应用情况作一综述。

Along with the progress of modern radiobiology, the radiotherapy oncologist had the profound understanding of the tumour cell repopulation and the impacts of single fractionation dosage on the later response normal tissues, and altering the fractionation schedule to improve cancer treatment efficacy as well as reduce the late normal tissue injuries. This review will focus on unconventional fractionation radiotherapy, such as hyperfraction radiotherapy alone, accelerated hyperfraction radiotherapy, conventional fractionation followed by accelerated hyperfraction, accelerated fractionation （6 or 7 fractions per week）, and its combination with chemotherapy, in treatment of nasopharyngeal carcinoma.