高压氧治疗糖尿病足的疗效评价

Evaluation of therapeutic effects of hyperbaric oxygen on patients with diabetic foot

目的观察糖尿病足患者,给予传统药物治疗和经高压氧治疗的不同疗效,探讨高压氧对糖尿病足患者治疗价值。方法将30例糖尿病足患者,根据患者志愿14例分为高压氧组(HBO),在传统药物治疗的基础上加高压氧治疗1h/d,共2周。另16例分为对照组给予传统药物治疗,观察2组患者治疗前及治疗2个月后患者C反应蛋白(CRP)、纤维蛋白原(FIB)、下肢血流峰值的变化,并且判断2组治疗2个月后的疗效。结果2组患者治疗前,C反应蛋白、纤维蛋白原、下肢血流速度差异均无显著性(P>0.05);治疗2个月后,HBO组患者C反应蛋白、纤维蛋白原、均低于治疗前及对照组治疗后(P<0.01),下肢动脉血流速度高于治疗前及对照组治疗后(P<0.01)。治疗2个月后,对照组总有效率为68.75%(11/16);高压氧组总有效率为85.71%(12/14),两组比较差异有统计学意义(P<0.01)。结论高压氧组对糖尿病足的治疗效果明显优于传统药物治疗,是一种安全有效的治疗方法。

Objective To explore the curative effect of hyperbaric oxygen on diabetic foot through comparing the efficacy of traditional therapy and hyperbaric oxygen. Methods 30 diabetic foot patients, 16 of them were given traditional therapy （control group）, the other 14 were treated by hyperbaric oxygen on a voluntary basis （HBO）. the levels of CRP,FIB and blood flow speed of the lower limbs between these two groups were compared before and after treatment. The treatment duration is 2 months. Results Before treatment,the difference of CRP,FIB and blood flow speed of the lower limbs in patients of both groups were not significant （P〉0.05）. Two months after treatment,the above parameters in HBO group were significantly improved compared to those in control group （P〈0.01）. Two months after treatment,the overall efficacy of HBO treatment was 85.71%（ 12/14）; while the traditional therapy was 68.75%（11/16）. The overall efficacy of HBO treatment was significantly higher than traditional therapy （P〈0.01）. Conclusion HBO treatment is more advantageous than the traditional therapy and it is a safe and effective therapy.