拉米夫定联合强的松治疗HBV感染原发性肾病综合征

Effect of lamivudine combined with prednisone on essential renal syndrome complicated with HBV

目的观察合并乙肝病毒(HBV)感染的原发性肾病综合征患者激素治疗过程中拉米夫定对HBV复制的防治效果。方法观察组18例合并HBV感染的原发性肾病综合征患者同时口服强的松及拉米夫定治疗;另外历史对照组20例患者未接受拉米夫定治疗,观察两组患者治疗前、治疗后血清HBVDNA定量、肝肾功能、尿蛋白定量的改变情况。结果观察组肝功能损害的发生率为13.3%,HBVDNA定量下降,对照组肝功能损害的发生率为44.4%,HBVDNA定量升高。结论合并HBV感染的原发性肾病综合征患者在激素同时预防应用拉米夫定能有效抑制HBVDNA复制,减少肝功能损害的发生率。

Objective To observe preventive and therapeutic effect of lamivudine on HBV replication in primary nephritic syndrome patients with HBV infection treated by prednisone; Methods The patients in lamivudine group consisted of 18 patients were treated with oral lamivudine and prednisone. Those in historical control group eonsisted of 20 patients were treated witht prednisone without lamivudine. The level of serum HBVDNA, 24h urine protein, liver and renal function of all patients were determined before and after treatment. Results The rate of liver injury was 13.3% in lamivudine group, while in control group it was 44.4%; HBVDNA indexes decreased in lamivudine group but it increased in control group. Conclusion The replication of HBVDNA can be inhibited in primary renal syndrome patients complicated with HBV infection after glueoeortieoid therapy and the incidenee of liver injury is also reduced.