摘要
目的探讨与肝脏损害有关的细胞因子IL-8、IL-12和TNF-α的变化在不同时期的肝硬化及不同肝功能状况的关系,以期阐明细胞因子检测在肝硬化失代偿发生临床意义和部分机制。方法研究选用肝硬化代偿期患者17例、失代偿期32例、肝硬化失代偿期合并自发性腹膜炎13例,共计62例;分别测定其静脉血血浆中IL-8、IL-12和TNF-α含量。检测采用ELISA方法。分析细胞因子在不同时期的肝硬化及不同肝功能状况的关系。结果细胞因子IL-8、IL-12和TNF-α在各组肝硬化患者均有不同程度的升高。且升高的程度与肝硬化患者病情的严重程度相一致。结论细胞因子升高的幅度与Child-Pugh分级标准评估的肝功能严重程度成正比。
Objective To observe the correlation of variations of levels of cytokines IL-8,TNF-α and IL-12 with cirrhosis patients. Methods There 62 cirrhosis patients were collected and the leveles of IL-8,IL-12,TNF-α were determined by ELISA. Results The levles of IL-8,1L-12 and TNF-α in patients of every group were increased in accordance with the severity of cirrhosis. Conclusion The increase of cytokincs was consistent with the severity of liver function.
出处
《中国热带医学》
CAS
2009年第8期1502-1502,1504,共2页
China Tropical Medicine
关键词
肝硬化
细胞因子
失代偿
Cirrhosis
Cytokines
Decompensation