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细胞因子IL-8、IL-12和TNF-α对肝硬化失代偿发生的意义

Level of cytokines IL-8 and IL-12 and TNF-α on lost of compensation of liver cirhosis
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摘要 目的探讨与肝脏损害有关的细胞因子IL-8、IL-12和TNF-α的变化在不同时期的肝硬化及不同肝功能状况的关系,以期阐明细胞因子检测在肝硬化失代偿发生临床意义和部分机制。方法研究选用肝硬化代偿期患者17例、失代偿期32例、肝硬化失代偿期合并自发性腹膜炎13例,共计62例;分别测定其静脉血血浆中IL-8、IL-12和TNF-α含量。检测采用ELISA方法。分析细胞因子在不同时期的肝硬化及不同肝功能状况的关系。结果细胞因子IL-8、IL-12和TNF-α在各组肝硬化患者均有不同程度的升高。且升高的程度与肝硬化患者病情的严重程度相一致。结论细胞因子升高的幅度与Child-Pugh分级标准评估的肝功能严重程度成正比。 Objective To observe the correlation of variations of levels of cytokines IL-8,TNF-α and IL-12 with cirrhosis patients. Methods There 62 cirrhosis patients were collected and the leveles of IL-8,IL-12,TNF-α were determined by ELISA. Results The levles of IL-8,1L-12 and TNF-α in patients of every group were increased in accordance with the severity of cirrhosis. Conclusion The increase of cytokincs was consistent with the severity of liver function.
机构地区 三亚市人民医院
出处 《中国热带医学》 CAS 2009年第8期1502-1502,1504,共2页 China Tropical Medicine
关键词 肝硬化 细胞因子 失代偿 Cirrhosis Cytokines Decompensation
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参考文献5

  • 1王智峰,王晶桐.肝硬化.∥王海燕.内科学.北京大学医学出版社,2005:559.
  • 2Miyamoto M, Shimizu Y, Okada K, et al. Effect of interleukin-8 on production of tumor associated substances and autocfine growth of human liver and pancreatic cancer cells [J] . Cancer Immunol Immunother, 1998, 47:47.
  • 3Tsukamoto H . Cytokine regulation of hepatic stellate cells in liver fibrosis Alcohol[ J ]. Clin Exp Res, 1999,23:911.
  • 4赵彩彦,周俊英,冯忠军,刘金星,汤慧华.病毒性肝炎患者IL-8、IL-10水平与肝功能损伤的关系[J].临床肝胆病杂志,2000,16(3):159-160. 被引量:8
  • 5F Torre,S Rossol,N Pell,et al . Kinetics of soluble tumor necrosis factor receptors and cytokines in the early phase of treatment for chronic hepatitis C: comparison between interferon (IFN)-α alone, IFN-α plus amantadine or plus ribavirin [J] . Clin Exp Immunol, 2004, June, 136 ( 3 ) : 50"7-512.

二级参考文献4

  • 1Huang YS,Chsn CY,Wu JC,et al.Serun levels of interleukin-8 in alcoholic liver disease:relationship with disease stage,biochemical parameters and survival[J].J Hepatol.1996,24(4):377.
  • 2Kakumu S,Okumra A.Ishikawa T,et al.Production of interleukin-10 and 12 by peripheral blood mononuclear cells in chrunie hepatitis C virus infection[J].Clin Exp Immunol ,1997,108(1):138.
  • 3Louis H,Le Moine O,Peny MO.et al.Prochuction and role of interleukin 10 in concanavalin A—induced hepatitis in mice[J].Hepatology.1997.25(6):1382.
  • 4朱传武,贺永文,罗端德.肝炎患者血清可溶性细胞间粘附分子-1与白细胞介素-8的检测及其意义[J].中华内科杂志,1997,36(9):625-626. 被引量:7

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